Southbound Interstate 5 is closed at milepost 210, about halfway between Albany and Eugene, due to a crash, according to the Oregon Department of Transportation.
The crash was reported by ODOT at 4 p.m. Saturday.
The highway may be closed for several hours, ODOT said. Drivers should use a different route or delay their trip.
Drivers should also expect delays just north of Creswell near milepost 184 due to another crash, the department said.
Makenzie Elliott covers breaking news and public safety for The Register-Guard. Reach her at MElliott@gannett.com. Find her on Twitter at @makenzielliott.